Recent advances in the investigation of curcuminoids

被引：133

作者：

Itokawa H. ^{[1
]}

Shi Q. ^{[1
]}

Akiyama T. ^{[1
]}

Morris-Natschke S.L. ^{[1
]}

Lee K.-H. ^{[1
]}

机构：

[1] Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill

来源：

Chinese Medicine | / 3卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Human Immunodeficiency Virus; Curcumin; Androgen Receptor; Human Prostate Cancer Cell Line; Bond Dissociation Enthalpy;

D O I：

10.1186/1749-8546-3-11

中图分类号：

学科分类号：

摘要：

More than 30 Curcuma species (Zingiberaceae) are found in Asia, where the rhizomes of these plants are used as both food and medicine, such as in traditional Chinese medicine. The plants are usually aromatic and carminative, and are used to treat indigestion, hepatitis, jaundice, diabetes, atherosclerosis and bacterial infections. Among the Curcuma species, C. longa, C. aromatica and C. xanthorrhiza are popular. The main constituents of Curcuma species are curcuminoids and bisabolane-type sesquiterpenes. Curcumin is the most important constituent among natural curcuminoids found in these plants. Published research has described the biological effects and chemistry of curcumin. Curcumin derivatives have been evaluated for bioactivity and structure-activity relationships (SAR). In this article, we review the literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant, anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids. Recent studies on curcuminoids, particularly on curcumin, have discovered not only much on the therapeutic activities, but also on mechanisms of molecular biological action and major genomic effects. © 2008 Itokawa et al; licensee BioMed Central Ltd.

引用

共 88 条

[1]

Kuhn M.A., Winston D., Herbal Therapy and Supplements: A Scientific & Traditional Approach, pp. 330-335, (2001)

[2]

Van Wyk B.E., Wink M., Medicinal Plants of the World, (2004)

[3]

Lee K.H., Antineoplastic agents and their analogues from Chinese traditional medicine, Human Medicinal Agents from Plants. Symp Series 534, pp. 170-190, (1993)

[4]

Itokawa H., Hirayama F., Funakoshi K., Takeya K., Studies on the antitumor bisabolane sesquiterpenoids isolated from Curcuma xanthorrhiza, Chem Pharm Bull, 33, pp. 3488-3492, (1985)

[5]

Uehara S., Yasuda I., Akiyama K., Morita H., Takeya K., Itokawa H., Diarylheptanoids from the rhizome of Curcuma xanthorrhiza and Alpinia officinarum, Chem Pharm Bull, 35, pp. 3298-3304, (1987)

[6]

Uehara S., Yasuda I., Takeya K., Itokawa H., New bisaborane sesquiterpenoids from the rhizomes of Curcuma xanthorrhiza (Zingiberaceae), Chem Pharm Bull, 37, pp. 237-240, (1989)

[7]

Uehara S., Yasuda I., Takeya K., Itokawa H., Iitaka Y., New bisaborane sesquiterpenoids from the rhizomes of Curcuma xanthorrhiza (Zingiberaceae) II, Chem Pharm Bull, 38, pp. 261-263, (1990)

[8]

Uehara S., Yasuda I., Takeya K., Itokawa H., Terpenoids and curcuminoids of the rhizoma of Curcuma xanthorrhiza Roxb, Yakugaku Zasshi, 112, pp. 817-823, (1992)

[9]

Uehara S., Yasuda I., Takeya K., Itokawa H., Comparison of the commercial turmeric and its cultivated plant by their constituents, Shouyakugaku Zasshi, 46, pp. 55-61, (1992)

[10]

Hwang J.K., Sim J.S., Baek N.I., Pyun Y.R., Xanthorrhizol: A potential antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans, Planta Med, 66, pp. 196-197, (2000)

← 1 2 3 4 5 6 7 8 9 →