Recent advances in the investigation of curcuminoids

被引：133

作者：

Itokawa H. ^{[1
]}

Shi Q. ^{[1
]}

Akiyama T. ^{[1
]}

Morris-Natschke S.L. ^{[1
]}

Lee K.-H. ^{[1
]}

机构：

[1] Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill

来源：

Chinese Medicine | / 3卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Human Immunodeficiency Virus; Curcumin; Androgen Receptor; Human Prostate Cancer Cell Line; Bond Dissociation Enthalpy;

D O I：

10.1186/1749-8546-3-11

中图分类号：

学科分类号：

摘要：

More than 30 Curcuma species (Zingiberaceae) are found in Asia, where the rhizomes of these plants are used as both food and medicine, such as in traditional Chinese medicine. The plants are usually aromatic and carminative, and are used to treat indigestion, hepatitis, jaundice, diabetes, atherosclerosis and bacterial infections. Among the Curcuma species, C. longa, C. aromatica and C. xanthorrhiza are popular. The main constituents of Curcuma species are curcuminoids and bisabolane-type sesquiterpenes. Curcumin is the most important constituent among natural curcuminoids found in these plants. Published research has described the biological effects and chemistry of curcumin. Curcumin derivatives have been evaluated for bioactivity and structure-activity relationships (SAR). In this article, we review the literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant, anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids. Recent studies on curcuminoids, particularly on curcumin, have discovered not only much on the therapeutic activities, but also on mechanisms of molecular biological action and major genomic effects. © 2008 Itokawa et al; licensee BioMed Central Ltd.

引用

共 88 条

[41]

Sharma O.P., Antioxidant activity of curcumin and related compounds, Biochem Pharmacol, 25, pp. 1811-1812, (1976)

[42]

Venkatesan P., Rao M.N.A., Structure-activity relationships for the inhibition of lipid peroxidation and the scavenging of free radicals by synthetic symmetrical curcumin analogues, J Pharm Pharmacol, 52, pp. 1123-1128, (2000)

[43]

Barclay L.R.C., Vinqvist M.R., Mukai K., Goto H., Tokunaga A., Uno H., On the antioxidant mechanism of curcumin: Classical methods are needed to determine antioxidant mechanism and activity, Organic Lett, 2, pp. 2841-2843, (2000)

[44]

Priyadarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G., Mohan H., Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin, Free Rad Biol Med, 35, pp. 475-484, (2003)

[45]

Gorman A.A., Hamblett I., Srinivasan V.S., Wood P.D., Curcumin-derived transients: A pulsed laser and pulse radiolysis study, Photochem Photobiol, 59, pp. 389-398, (1994)

[46]

Priyadarsini K.I., Free radical reactions of curcumin in membrane models, Free Rad Biol Med, 23, pp. 838-843, (1997)

[47]

Khopde S.M., Priyadarsini K.I., Venkatesan P., Rao M.N.A., Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue, Biophys Chem, 80, pp. 85-91, (1999)

[48]

Kapoor S., Priyadarsini K.I., Protection of radiation-induced protein damage by curcumin, Biophys Chem, 92, pp. 119-126, (2001)

[49]

Jovanovic S.V., Steenken S., Boone C.W., Simic G., How curcumin works preferentially with water soluble antioxidants, J Am Chem Soc, 121, pp. 9677-9681, (1999)

[50]

Patro B.S., Rele S., Chhintalwar G.J., Chattopadhyay S., Adhikari S., Mukerjee T., Protective activities of some phenolic 1,3-diketones against lipid peroxidation: Possible involvement of the 1,3-diketone moiety, Chembiochem, 3, pp. 364-370, (2002)

← 1 2 3 4 5 6 7 8 9 →