HIV accessory proteins and surviving the host cell.

被引:19
作者
Anderson J.L. [1 ]
Hope T.J. [1 ]
机构
[1] Department of Microbiology and Immunology, The University of Illinois at Chicago, Chicago, 60612, IL
基金
美国国家卫生研究院;
关键词
Virion Release; Viral Infectivity Factor; Human APOBEC3G; Enhance Virion Infectivity; Enhance Virion Release;
D O I
10.1007/s11904-004-0007-x
中图分类号
学科分类号
摘要
Human immunodeficiency virus generates the accessory proteins Nef, viral infectivity factor (Vif), viral protein R, and viral protein U or viral protein X during viral replication in host cells. Although the significance of these accessory proteins is often lost in vitro, they are essential for viral pathogenesis in vivo. Therefore, these proteins have much potential as antiviral targets. Recent data reveal Vif perturbs an ill-defined antiviral pathway in host cells allowing HIV replication. These data highlight a common feature among HIV accessory proteins in manipulating the host to aid viral pathogenesis. Therefore, these new insights into Vif and other HIV accessory proteins are reviewed, emphasizing host cell interactions and new targets for therapeutic intervention.
引用
收藏
页码:47 / 53
页数:6
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