Intravenous Cereport (RMP-7) Enhances Delivery of Hydrophilic Chemotherapeutics and Increases Survival in Rats with Metastatic Tumors in the Brain

被引：10

作者：

Dwaine F Emerich

Reginald L Dean

JoAnne Marsh

Melissa Pink

Denise Lafreniere

Pamela Snodgrass

Raymond T Bartus

机构：

[1] Alkermes,Department of Pharmacology

[2] Inc.,Department of Pharmacology and Experimental Therapeutics

[3] Alkermes,undefined

[4] Inc.,undefined

[5] Tufts University Medical Center,undefined

来源：

Pharmaceutical Research | 2000年 / 17卷

关键词：

blood-brain tumor barrier; bradykinin; brain metastases; carboplatin; carmustine; paclitaxel; vinorelbine; gemcitabine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. The following experiments determined whether intravenous infusions of Cereport enhance delivery of chemotherapeutics and prolong survival in rats with metastatic tumors in the brain.

引用

页码：1212 / 1219

页数：7

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