Focal small bowel perforation: An adverse effect of early postnatal dexamethasone therapy in extremely low birth weight infants

被引：31

作者：

Gordon P.V. ^{[1
]}

Young M.L. ^{[2
]}

Marshall D.D. ^{[1
]}

机构：

[1] Department of Pediatrics, University of North Carolina, Chapel Hill, NC

[2] Department of Biostatistics, University of North Carolina, Chapel Hill, NC

来源：

Journal of Perinatology | 2001年 / 21卷 / 3期

关键词：

D O I：

10.1038/sj.jp.7200520

中图分类号：

学科分类号：

摘要：

Objective: We tested the hypothesis that early postnatal dexamethasone (EPD) increases the risk of focal small bowel perforation (FSBP) in extremely low birth weight (ELBW) infants. Study Design: The techniques of meta-analysis were applied to studies evaluating EPD, which we identified through a systematic literature search. Studies were included if they were randomized, placebo-controlled trials of EPD, enrolled infants with birth weights ≤1000 g, and reported FSBP as an outcome variable. The Breslow-Day test was used to assess for homogeneity and a summary odds ratio was calculated using the Mantel-Haenszel exact method. Results: Four studies, with a pooled sample of 1383 infants, were included in the primary analysis. The Breslow-Day test showed a p-value of 0.61, indicating homogeneity among the studies. FSBP was significantly higher in EPD treated infants [odds ratio 1.91, 95% confidence interval (CI) 1.21, 3.07; p = 0.004]. Conclusion: EPD increases the risk of FSBP in ELBW infants.

引用

页码：156 / 160

页数：4

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