Point-of-care testing

被引：41

作者：

Anderson D.A. ^{[1
,2
]}

Crowe S.M. ^{[1
,3
]}

Garcia M. ^{[1
]}

机构：

[1] Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, VIC 3004

[2] Department of Microbiology, Department of Immunology, Monash University, Melbourne, VIC 3004

[3] Department of Medicine, Monash University, Melbourne, VIC 3004

来源：

Current HIV/AIDS Reports | 2011年 / 8卷 / 1期

关键词：

CD4; HIV; Monitoring; Neonatal diagnosis; p24; PCR; Pima; Point of care; Rapid testing; Viral load;

D O I：

10.1007/s11904-010-0067-z

中图分类号：

学科分类号：

摘要：

The availability of rapid, point-of-care (POC) tests has significantly expanded the capacity of both developed and resource-constrained countries (RCCs) to diagnose HIV, with immunochromatographic tests most commonly used in these settings. This has been especially important in programs for prevention of mother-to-child transmission, in both RCCs and the developed world. However, suitable POC tests are not yet commercially available for diagnosis of neonatal HIV, where persistence of maternal antibody in the infant precludes the use of current antibody tests during the first 12 to 18 months. In addition, measurement of CD4+ T cells, CD4%, and HIV viral load still relies on sophisticated laboratory infrastructure, constraining the delivery of appropriate care to many HIV-infected patients. Continued effort is required in the development and validation of additional POC tests to support HIV patient care, and in quality assurance in manufacturing and in test performance in the field to ensure appropriate use of existing and new POC tests. © 2010 Springer Science+Business Media, LLC.

引用

页码：31 / 37

页数：6

共 42 条

[21] MacLennan C.A., Van Oosterhout J.J., White S.A., Et al., Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests, AIDS, 21, pp. 1643-1645, (2007)
[22] Pima CD4 Test and Analyzer
[23] How the Test Works
[24] CD4 Test Press Release
[25] Cheng X., Gupta A., Chen C., Et al., Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics, Lab Chip, 9, pp. 1357-1364, (2009)
[26] Jokerst J.V., Floriano P.N., Christodoulides N., Et al., Integration of semiconductor quantum dots into nano-bio-chip systems for enumeration of CD4+ T cell counts at the point-of-need, Lab Chip, 8, pp. 2079-2090, (2008)
[27] Li X., Breukers C., Ymeti A., Et al., Clinical evaluation of a simple image cytometer for CD4 enumeration on HIV-infected patients, Cytometry B Clin Cytom, 78, pp. 31-36, (2010)
[28] Moon S., Keles H.O., Ozcan A., Et al., Integrating microfluidics and lensless imaging for point-of-care testing, Biosens Bioelectron, 24, pp. 3208-3214, (2009)
[29] Seo S., Su T.W., Tseng D.K., Et al., Lensfree holographic imaging for on-chip cytometry and diagnostics, Lab Chip, 9, pp. 777-787, (2009)
[30] Jangam S.R., Yamada D.H., McFall S.M., Et al., Rapid, point-of-care extraction of human immunodeficiency virus type 1 proviral DNA from whole blood for detection by real-time PCR, J Clin Microbiol, 47, pp. 2363-2368, (2009)

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