Opioid and Cannabinoid Receptors Share a Common Pool of GTP-Binding Proteins in Cotransfected Cells, But Not in Cells Which Endogenously Coexpress the Receptors

被引：50

作者：

Ma'anit Shapira ^{[1
]}

Zvi Vogel ^{[2
]}

Yosef Sarne ^{[1
]}

机构：

[1] Tel-Aviv University,Department of Physiology and Pharmacology, Sackler Faculty of Medicine

[2] The Weizmann Institute of Science,Department of Neurobiology

[3] Tel-Aviv University,The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine

来源：

Cellular and Molecular Neurobiology | 2000年 / 20卷 / 3期

关键词：

opioid receptors; cannabinoid receptors; GTP-binding proteins; cell transfection; [; S]GTPγS binding; neuroblastoma;

D O I：

10.1023/A:1007058008477

中图分类号：

学科分类号：

摘要：

1. Opioid (μ, δ, κ) and cannabinoid (CB1, CB2) receptors are coupled mainly toGi/Go GTP-binding proteins. The goal of the present study was to determine whether different subtypes of opioid and cannabinoid receptors, when coexpressed in the same cell, share a common reservoir, or utilize different pools, of G proteins.

引用

页码：291 / 304

页数：13

共 130 条

[1]

Baumhaker Y.(1993)Selective and interactive down-regulation of Mol. Pharmacol. 44 461-467

[2]

Gafni M.(1997)-and J. Biol. Chem. 272 22330-22339

[3]

Keren O.(1997)-opioid receptors in human neuroblastoma SK-N-SH cells J. Neurochem. 68 462-1472

[4]

Sarne Y.(1995)A selective inverse agonist for central cannabinoid receptor inhibit mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1 J. Neurochem. 64 2534-2543

[5]

Bouaboula M.(1995)Acute and chronic effects of opioids on J. Neurochem. 65 2682-2689

[6]

Perrachon S.(1991) and Life Sci. 48 1991-2003

[7]

Milligan L.(1986) receptors activation of G proteins in NG108-15 and SK-N-SH cell membranes J. Neurochem. 46 1929-1935

[8]

Canat X.(1992)Expression of the Science 258 1952-1955

[9]

Rinaldi-Carmona M.(1997)-opioid receptor in CHO cells: Ability of J. Neurosci. 17 5327-5333

[10]

Portier M.(1989)-opioid ligands to promote Mol. Pharmacol. 38 265-272

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