Opioid and Cannabinoid Receptors Share a Common Pool of GTP-Binding Proteins in Cotransfected Cells, But Not in Cells Which Endogenously Coexpress the Receptors

被引：50

作者：

Ma'anit Shapira ^{[1
]}

Zvi Vogel ^{[2
]}

Yosef Sarne ^{[1
]}

机构：

[1] Tel-Aviv University,Department of Physiology and Pharmacology, Sackler Faculty of Medicine

[2] The Weizmann Institute of Science,Department of Neurobiology

[3] Tel-Aviv University,The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine

来源：

Cellular and Molecular Neurobiology | 2000年 / 20卷 / 3期

关键词：

opioid receptors; cannabinoid receptors; GTP-binding proteins; cell transfection; [; S]GTPγS binding; neuroblastoma;

D O I：

10.1023/A:1007058008477

中图分类号：

学科分类号：

摘要：

1. Opioid (μ, δ, κ) and cannabinoid (CB1, CB2) receptors are coupled mainly toGi/Go GTP-binding proteins. The goal of the present study was to determine whether different subtypes of opioid and cannabinoid receptors, when coexpressed in the same cell, share a common reservoir, or utilize different pools, of G proteins.

引用

页码：291 / 304

页数：13

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