Quantitative trait linkage studies of diabetes-related traits

被引：7

作者：

Robert L. Hanson

William C. Knowler

机构：

[1] National Institute of Diabetes and Digestive and Kidney Diseases,Diabetes and Arthritis Epidemiology Section

来源：

Current Diabetes Reports | 2003年 / 3卷 / 2期

关键词：

Insulin Secretion; Linkage Study; Genomewide Linkage; Quantitative Trait Linkage; Affected Relative Pair;

D O I：

10.1007/s11892-003-0042-9

中图分类号：

学科分类号：

摘要：

Genetic linkage methods for diseases with complex inheritance are based on assessment of allele sharing between affected relative pairs, but such methods have low power to detect genes with moderate effects. This may explain the difficulty in replication for many of the putative loci for type 2 diabetes. To enhance power to detect diabetes-susceptibility genes, some investigators have performed quantitative-trait linkage studies for diabetes-related traits, including measures of glycemia, insulin sensitivity, insulin secretion, obesity, lipidemia, and blood pressure. These linkage studies have not provided stronger or more consistent evidence for linkage than studies of diabetes affection status, but have identified several loci that may play an important role in the physiologic processes related to the development of type 2 diabetes.

引用

页码：176 / 183

页数：7

共 145 条

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