Brain bank of the Brazilian aging brain study group - A milestone reached and more than 1,600 collected brains

被引：111

作者：

Grinberg L.T. ^{[1
]}

Lucena Ferretti R.E. ^{[2
]}

Farfel J.M. ^{[2
]}

Leite R. ^{[1
]}

Pasqualucci C.A. ^{[1
]}

Rosemberg S. ^{[1
]}

Nitrini R. ^{[3
]}

Saldiva P.H.N. ^{[1
]}

Jacob Filho W. ^{[1
]}

机构：

[1] Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, SP 01246-903, Avenida Dr. Arnaldo

[2] Division of Geriatrics, University of Sao Paulo Medical School, Sao Paulo, SP

[3] Department of Neurology, University of Sao Paulo Medical School, Sao Paulo, SP

来源：

Cell and Tissue Banking | 2007年 / 8卷 / 2期

基金：

巴西圣保罗研究基金会;

关键词：

Aging; Alzheimer's disease; Brainbanking; Dementia; Geriatrics; Neurodegenerative diseases; Neurology; Neuropathology;

D O I：

10.1007/s10561-006-9022-z

中图分类号：

学科分类号：

摘要：

Introduction: Brain banking remains a necessity for the study of aging brain processes and related neurodegenerative diseases. In the present paper, we report the methods applied at and the first results of the Brain Bank of the Brazilian Aging Brain Study Group (BBBABSG) which has two main aims: (1) To collect a large number of brains of elderly comprising non-demented subjects and a large spectrum of pathologies related to aging brain processes, (2) To provide quality material to a multidisciplinar research network unraveling multiple aspects of aging brain processes and related neurodegenerative diseases. Methods: The subjects are selected from the Sao Paulo Autopsy Service. Brain parts are frozen and fixated. CSF, carotids, kidney, heart and blood are also collected and DNA is extracted. The neuropathological examinations are carried out based on accepted criteria, using immunohistochemistry. Functional status are assessed through a collateral source based on a clinical protocol. Protocols are approved by the local ethics committee and a written informed consent form is obtained. Results: During the first 21 months, 1,602 samples were collected and were classified by Clinical Dementia Rating as CDR0: 65.7%; CDR0.5:12.6%, CDR1:8.2%, CDR2:5.4%, and CDR3:8.1%. On average, the cost for the processing each case stood at US$400. To date, 14 laboratories have been benefited by the BBBABSG. Conclusion: The high percentage of non-demented subjects and the ethnic diversity of this series may be significantly contributive toward aging brain processes and related neurodegenerative diseases understanding since BBBABSG outcomes may provide investigators the answers to some additional questions. © Springer Science+Business Media B.V. 2006.

引用

页码：151 / 162

页数：11

共 40 条

[11]

Ferri C.P., Prince M., Brayne C., Et al., Global prevalence of dementia: A Delphi consensus study, Lancet, 366, pp. 2112-2117, (2005)

[12]

Harrison P.J., Advances in post mortem molecular neurochemistry and neuropathology: Examples from schizophrenia research, Br Med Bull, 52, pp. 527-538, (1996)

[13]

Herrera Jr. E., Caramelli P., Silveira A.S., Et al., Epidemiologic survey of dementia in a community-dwelling Brazilian population, Alzheimer Dis Assoc Disord, 16, pp. 103-108, (2002)

[14]

Hulette C., Brain banking in the United States, J Neuropathol Exp Neurol, 62, pp. 715-722, (2003)

[15]

Isella V., Villa L., Russo A., Et al., Discriminative and predictive power of an informant report in mild cognitive impairment, J Neurol Neurosurg Psychiatr, 77, pp. 166-171, (2006)

[16]

Jorm A.F., A short form of the informant questionnaire on cognitive decline in the elderly (IQCODE): Development and cross-validation, Psychol Med, 24, pp. 145-153, (1994)

[17]

Jorm A.F., Methods of screening for dementia: A meta-analysis of studies comparing an informant questionnaire with a brief cognitive test, Alzheimer Dis Assoc Disord, 11, pp. 158-162, (1997)

[18]

Katz S., Ford A.B., Moskowitz R.W., Et al., Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychological function, JAMA, 185, pp. 914-919, (1963)

[19]

Lawton M.P., Brody E.M., Assessment of older people: Self-maintaining and instrumental activities of daily living, Gerontologist, 9, pp. 179-186, (1969)

[20]

Love S., Post mortem sampling of the brain and other tissues in neurodegenerative disease, Histopathology, 44, pp. 309-317, (2004)

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