Age and immunity

被引：32

作者：

Vasto S. ^{[1
]}

Malavolta M. ^{[2
]}

Pawelec G. ^{[3
]}

机构：

[1] Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo

[2] Immunology Ctr., Sec.: Nutrition Immunity and Ageing, Res. Dept. INRCA, Ancona

[3] Center for Medical Research, University of Tübingen

来源：

Immunity & Ageing | / 3卷 / 1期

关键词：

Human Leukocyte Antigen; Telomere Length; Lipid Raft; Carnosine; Immune Risk Profile;

D O I：

10.1186/1742-4933-3-2

中图分类号：

学科分类号：

摘要：

Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest. © 2006 Vasto et al; licensee BioMed Central Ltd.

引用

共 26 条

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[2]

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