Age and immunity

被引：32

作者：

Vasto S. ^{[1
]}

Malavolta M. ^{[2
]}

Pawelec G. ^{[3
]}

机构：

[1] Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo

[2] Immunology Ctr., Sec.: Nutrition Immunity and Ageing, Res. Dept. INRCA, Ancona

[3] Center for Medical Research, University of Tübingen

来源：

Immunity & Ageing | / 3卷 / 1期

关键词：

Human Leukocyte Antigen; Telomere Length; Lipid Raft; Carnosine; Immune Risk Profile;

D O I：

10.1186/1742-4933-3-2

中图分类号：

学科分类号：

摘要：

Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest. © 2006 Vasto et al; licensee BioMed Central Ltd.

引用

共 26 条

[11]

Balistreri C.R., Candore G., Colonna-Romano G., Lio D., Caruso M., Hoffmann E., Franceschi C., Caruso C., Role of Toll-like receptor 4 in acute myocardial infarction and longevity, JAMA, 17, 292, pp. 2339-2340, (2004)

[12]

Naumova E., Mihaylova A., Ivanova M., Michailova S., Penkova K., Baltadjieva D., Immunological markers contributing to successful aging in Bulgarians, Exp Gerontol, 39, pp. 637-644, (2004)

[13]

Mocchegiani E., Bertoni-Freddari C., Marcellini F., Malavolta M., Brain, aging and neurodegeneration: Role of zinc ion availability, Prog Neurobiol, 75, pp. 367-390, (2005)

[14]

Pawelec G., Akbar A., Caruso C., Effros R., Grubeck-Loebenstein B., Wikby A., Is immunosenescence infectious?, Trends Immunol, 25, pp. 406-410, (2004)

[15]

Witkowski J.M., Bryl E., Paradoxical age-related cell cycle quickening of human CD4+ lymphocytes

[16]

a role for cyclin D1 and calpain, Experimental Gerontology, 39, pp. 577-585, (2004)

[17]

Wikby A., Ferguson F., Forsey R., Thompson J., Strindhall J., Lofgren S., Nilsson B.O., Ernerudh J., Pawelec G., Johansson B., An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans, J Gerontol A Biol Sci Med Sci, 60, pp. 556-565, (2005)

[18]

Fulop Jr. T., Larbi A., Dupuis G., Pawelec G., Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - A biochemical paradigm for the ageing immune system, Arthritis Res Ther, 5, pp. 290-302, (2003)

[19]

Larbi A., Dupuis G., Khalil A., Douziech N., Fortin C., Fulop Jr. T., Differential role of lipid rafts in the functions of CD4(+) and CD8(+) human T lymphocytes with aging, Cell Signal, (2005)

[20]

Larbi A., Dupuis G., Douziech N., Khalil A., Fulop Jr. T., Low-grade inflammation with aging has consequences for T-lymphocyte signaling, Ann N Y Acad Sci, 1030, pp. 125-133, (2004)

← 1 2 3 →