Salvage therapy for ovarian cancer.

被引:13
作者
Garcia A.A. [1 ]
机构
[1] Division of Medical Oncology, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS 34, Los Angeles, 90089-9177, CA
关键词
Ovarian Cancer; Paclitaxel; Docetaxel; Clin Oncol; Epithelial Ovarian Cancer;
D O I
10.1007/s11912-999-0012-8
中图分类号
学科分类号
摘要
The majority of patients with ovarian cancer will relapse after initial chemotherapy and will be candidates for salvage treatment. Currently, five agents show clear activity in patients with platinum- and paclitaxel-resistant disease: topotecan, oral etoposide, liposomal doxorubicin, gemcitabine, and, possibly, docetaxel. In addition, other agents have activity in platinum-resistant patients: vinorelbine, tamoxifen, ifosfamide, altretamine, 5-fluorouracil with leucovorin, and, possibly, irinotecan. Furthermore, selected patients may benefit from other therapeutic approaches such as surgery or radiation therapy.
引用
收藏
页码:64 / 70
页数:6
相关论文
共 196 条
[31]  
Blessing JA(1995)Gemcitabine (gem) in cisplatin-resistant ovarian cancer [abstract] Proc ASCO 14 272-272
[32]  
Ball H(1995)Docetaxel J Clin Oncol 13 2643-2655
[33]  
Trimble EL(1995)Docetaxel: an active new drug for treatment of advanced epithelial ovarian cancer J Natl Cancer Inst 87 676-681
[34]  
Adams JD(1996)Phase II study of docetaxel in patients with epithelial ovarian carcinoma refractory to platinum Clin Cancer Res 2 837-842
[35]  
Vena D(1994)Phase II trial of docetaxel in patients with platinum-refractory advanced ovarian cancer J Clin Oncol 12 2301-2308
[36]  
Einzig AI(1997)Phase II trials of docetaxel (Taxotere) in advanced ovarian cancer-an updated review Eur J Cancer 33 2167-2170
[37]  
Wiernik PH(1998)A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer J Clin Oncol 16 3362-3368
[38]  
Sasloff D(1999)Docetaxel for patients with ovarian cancer refractory to paclitaxel, an update [abstract] Proc Asco 18 368a-368a
[39]  
Fennelly C(1997)Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation J Clin Oncol 15 987-993
[40]  
Aghajanian F(1999)Interim analysis of a non-comparative, multicenter study of DOXIL/CAELYX in the treatment of patients with refractory ovarian cancer [abstract] Proc ASCO 18 360a-360a