IMMUNOPATHOGENESIS AND TREATMENT OF THE GUILLAIN-BARRE-SYNDROME .2.

被引：96

作者：

HARTUNG, HP ^{[1
]}

POLLARD, JD ^{[1
]}

HARVEY, GK ^{[1
]}

TOYKA, KV ^{[1
]}

机构：

[1] UNIV SYDNEY,INST CLIN NEUROSCI,SYDNEY,NSW 2006,AUSTRALIA

来源：

MUSCLE & NERVE | 1995年 / 18卷 / 02期

关键词：

GUILLAIN-BARRE SYNDROME; CAMPYLOBACTER JEJUNI; GANGLIOSIDE ANTIBODIES; MOLECULAR MIMICRY; PLASMA EXCHANGE; IVIG; MANAGEMENT;

D O I：

10.1002/mus.880180203

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the second part of our review the role of antecedent infections in the pathogenesis of GBS is discussed, The association with Campylobacter jejuni (C. jejuni) is highlighted and the concept of molecular mimicry, i.e., sharing of epitopes between microbes and peripheral nerve, explained. Alternative mechanisms to relate an infection with the immune-mediated neuropathy are elaborated, Current therapies of the GBS include plasma exchange, high-dose intravenous immunoglobulins, and supportive treatment directed to secondary complications. Published therapeutic trials are reviewed and future approaches are outlined. Principles of general care are also summarized. (C) 1995 John Wiley and Sons, Inc.

引用

页码：154 / 164

页数：11

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