RESULTS OF A MULTICENTER TRIAL USING THE BTA TEST TO MONITOR FOR AND DIAGNOSE RECURRENT BLADDER-CANCER

被引：194

作者：

SAROSDY, MF

WHITE, RWD

SOLOWAY, MS

SHEINFELD, J

HUDSON, MA

SCHELLHAMMER, PF

JAROWENKO, MV

ADAMS, G

BLUMENSTEIN, BA

机构：

[1] UNIV MIAMI,SCH MED,DEPT UROL,NEW YORK,NY

[2] UNIV CALIF DAVIS,SCH MED,DEPT UROL,DAVIS,CA 95616

[3] WASHINGTON UNIV,DEPT UROL,ST LOUIS,MO

[4] MEM SLOAN KETTERING CANC CTR,DEPT UROL,NEW YORK,NY 10021

[5] EASTERN VIRGINIA MED SCH,DEPT UROL,NORFOLK,VA

[6] PENN STATE UNIV HOSP,DEPT UROL,HERSHEY,PA

[7] SORRA NC RES CTR,DEPT UROL,BIRMINGHAM,AL

[8] FRED HUTCHINSON CANC RES CTR,DEPT UROL,SEATTLE,WA 98104

来源：

JOURNAL OF UROLOGY | 1995年 / 154卷 / 02期

关键词：

NEOPLASM METASTASIS; BLADDER NEOPLASMS; NEOPLASM ANTIGENS; ANTIBODY SPECIFICITY;

D O I：

10.1016/S0022-5347(01)67054-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: We compare the Bard BTA (bladder tumor antigen) test to voided cytology studies in patients undergoing surveillance cystoscopy for recurrent bladder cancer. Materials and Methods: A prospective, blinded, multicenter trial was performed. Results: A total of 499 patients underwent 1,014 cystoscopic examinations and tumor was identified in 151. The bladder tumor antigen test was more sensitive than cytology studies in detecting recurrent cancer (p<0.001), being positive in 61 cases versus 25 for cytology. The trial in healthy volunteers and nonurological patients estimates bladder tumor antigen test specificity to be 95.9%. Conclusions: The bladder tumor antigen test is a simple, rapid and inexpensive adjunct to cystoscopy, and the results are equivalent or superior to those of voided cytology as performed in this trial,

引用

页码：379 / 383

页数：5

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