2 SYSTEMS FOR THE AUTOMATED-ANALYSIS OF DRUGS IN BIOLOGICAL-FLUIDS USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：15

作者：

DOYLE, E

MCDOWALL, RD

MURKITT, GS

PICOT, VS

ROGERS, SJ

机构：

[1] Department of Drug Analysis, Smith Kline and French Research Ltd., Welwyn, Hertfordshire AL6 9AR, The Frythe

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 527卷 / 01期

关键词：

D O I：

10.1016/S0378-4347(00)82084-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes two fully automated assays. One for zaprinast, a cGMP specific phosphodiesterase inhibitor, which uses the Gilson-Advanced Automated Sample Processor combination, and the other for an H+/K+ ATPase inhibitor and its sulphone metabolite, which uses direct injection. Both assays were developed to support pharmacokinetic studies at therapeutic doses in small animals as well as in man. Plasma or serum (20-200 μl) is placed directly into an autosampler and all subsequent manipulations are performed mechanically. © 1990.

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页码：67 / 77

页数：11

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