BIOSYNTHESIS OF BENASTATIN-A

被引：13

作者：

AOYAMA, T ^{[1
]}

NAGANAWA, H ^{[1
]}

MURAOKA, Y ^{[1
]}

AOYAGI, T ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI,MACHIDA,TOKYO 194,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 11期

关键词：

D O I：

10.7164/antibiotics.45.1767

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The biosynthesis of benastatin A, produced by Streptomyces sp. MI384-DF12, has been studied by feeding experiments with C-14 and C-13-labeled compounds followed by measurement of radioactivity and C-13 NMR analysis. The results indicate that benastatin A is derived from two methionine units and fourteen acetate units, condensed in the "head-to-tail" fashion of typical polyketide biosynthesis.

引用

收藏

页码：1767 / 1772

页数：6

相关论文

共 8 条

[1] BENASTATIN-A AND BENASTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 .1. TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES [J].

AOYAGI, T ;

AOYAMA, T ;

KOJIMA, F ;

MATSUDA, N ;

MARUYAMA, M ;

HAMADA, M ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (09) :1385-1390

[2] BENASTATIN-A AND BENASTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 .2. STRUCTURE DETERMINATION OF BENASTATIN-A AND BENASTATIN-B [J].

AOYAMA, T ;

NAGANAWA, H ;

MURAOKA, Y ;

NAKAMURA, H ;

AOYAGI, T ;

TAKEUCHI, T ;

ITAKA, Y .

JOURNAL OF ANTIBIOTICS, 1992, 45 (09) :1391-1396

[3] BIOSYNTHESIS OF THE BORON-CONTAINING MACROLIDE ANTIBIOTIC APLASMOMYCIN BY STREPTOMYCES-GRISEUS [J].

CHEN, TSS ;

CHANG, CJ ;

FLOSS, HG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (15) :4565-4568

[4] NOVEL BENZO[A]NAPHTHACENE QUINONES FROM AN ACTINOMYCETE, FRANKIA G-2 (ORS 020604) [J].

GERBER, NN ;

LECHEVALIER, MP .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1984, 62 (12) :2818-2821

[5] BIOSYNTHESIS OF BENANOMICINS [J].

GOMI, S ;

SEZAKI, M ;

HAMADA, M ;

KONDO, S ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1989, 42 (07) :1145-1150

[6]

HOFLE G, 1983, LIEBIGS ANN CHEM, P835

[7] BIOSYNTHESIS OF PRADIMICIN-A [J].

KAKUSHIMA, M ;

SAWADA, Y ;

NISHIO, M ;

TSUNO, T ;

OKI, T .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (11) :2536-2539

[8] STRUCTURE OF A NOVEL CA-2+ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR KS-619-1 [J].

YASUZAWA, T ;

YOSHIDA, M ;

SHIRAHATA, K ;

SANO, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (08) :1111-1114