PROGESTERONE-RECEPTOR AND NEUROTENSIN ARE COLOCALIZED IN NEURONS OF THE GUINEA-PIG VENTROLATERAL HYPOTHALAMUS

被引：12

作者：

WAREMBOURG, M ^{[1
]}

JOLIVET, A ^{[1
]}

机构：

[1] FAC MED PARIS SUD,INSERM,U135,LE KREMLIN BICETR,FRANCE

来源：

NEUROENDOCRINOLOGY | 1994年 / 60卷 / 05期

关键词：

GONADAL STEROID RECEPTORS; NEUROTENSIN; LATERAL HYPOTHALAMUS; GUINEA PIG; IMMUNOCYTOCHEMISTRY;

D O I：

10.1159/000126785

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A double-labeling immunofluorescence procedure was used to determine whether progesterone receptor (PR)-containing neurons in the mediobasal hypothalamus of female guinea pig also contain neurotensin (NT). Animals were ovariectomized, primed by estradiol to induce PR and injected intracerebroventricularly with colchicine to visualize NT-immunopositive neurons. Approximatively 24% of the NT-immunoreactive (IR) neurons in the ventrolateral nucleus (VL) displayed PR immunoreactivity, accounting for 4% of the total population of cells containing PR in this region. The arcuate nucleus (AR) was observed to have both populations, but coexistence was rare. These findings provide neuroanatomical evidence that a subset of NT neurons is directly regulated by progesterone in the VL, a site that plays a key role in the control of female sexual behavior.

引用

页码：486 / 492

页数：7

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