GERI-BP001, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS F37

被引:14
作者
JEONG, TS
KIM, SU
KWON, BM
SON, KH
KIM, YK
CHOI, MU
BOK, SH
机构
[1] KIST,GENET ENGN RES INST,BIOPROD RES GRP,TAEJON 305600,SOUTH KOREA
[2] SEOUL NATL UNIV,COLL NAT SCI,DEPT CHEM,SEOUL 151742,SOUTH KOREA
关键词
D O I
10.1016/S0040-4039(00)73240-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
GERI-BP001, a new inhibitor (IC50 50 mu M) of acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from a culture broth of Aspergillus fumigatus F37 and the structure elucidated on the basis of spectroscopic data.
引用
收藏
页码:3569 / 3570
页数:2
相关论文
共 6 条
[1]  
BELL FP, 1986, PHARM CONTROL HYPERL, P409
[2]   AS-183, A NOVEL INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY SCEDOSPORIUM SP SPC-15549 [J].
KURODA, K ;
YOSHIDA, M ;
UOSAKI, Y ;
ANDO, K ;
KAWAMOTO, I ;
OISHI, E ;
ONUMA, H ;
YAMADA, K ;
MATSUDA, Y .
JOURNAL OF ANTIBIOTICS, 1993, 46 (08) :1196-1202
[3]   PYRIPYROPENES, HIGHLY POTENT INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS [J].
OMURA, S ;
TOMODA, H ;
KIM, YK ;
NISHIDA, H .
JOURNAL OF ANTIBIOTICS, 1993, 46 (07) :1168-1169
[4]   THERAPEUTIC POTENTIAL OF ACAT INHIBITORS AS LIPID LOWERING AND ANTIATHEROSCLEROTIC AGENTS [J].
SLISKOVIC, DR ;
WHITE, AD .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (05) :194-199
[5]  
TABAS I, 1986, J BIOL CHEM, V261, P3147
[6]   PURPACTINS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY PENICILLIUM-PURPUROGENUM .1. PRODUCTION, ISOLATION AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES [J].
TOMODA, H ;
NISHIDA, H ;
MASUMA, R ;
CAO, J ;
OKUDA, S ;
OMURA, S .
JOURNAL OF ANTIBIOTICS, 1991, 44 (02) :136-143