RECURRENT MENINGOCOCCAL SEPTICEMIA AND PROPERDIN DEFICIENCY

被引：22

作者：

CUNLIFFE, NA

SNOWDEN, N

DUNBAR, EM

HAENEY, MR

机构：

[1] N MANCHESTER GRP HOSP,DEPT INFECT DIS & TROP MED,MONSALL UNIT,MANCHESTER,LANCS,ENGLAND

[2] HOPE HOSP,DEPT IMMUNOL,SALFORD M6 8HD,LANCS,ENGLAND

来源：

JOURNAL OF INFECTION | 1995年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0163-4453(95)91550-8

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A 32-year-old male presented with two episodes of meningococcal septicaemia, each of which was caused by a different serogroup of Neisseria meningitidis. Examination of the alternative pathway of complement revealed the rare X-linked disorder properdin deficiency (PD). Meningococcal infection in complement deficiency states is discussed and the unusual features of this case are highlighted.

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页码：67 / 68

页数：2

相关论文

共 12 条

[1]

DENSEN P, 1991, Clinical and Experimental Immunology, V86, P57

[2] FAMILIAL PROPERDIN DEFICIENCY AND FATAL MENINGOCOCCEMIA - CORRECTION OF THE BACTERICIDAL DEFECT BY VACCINATION [J].

DENSEN, P ;

WEILER, JM ;

GRIFFISS, JM ;

HOFFMANN, LG .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (15) :922-926

[3] INFECTIOUS-DISEASES ASSOCIATED WITH COMPLEMENT DEFICIENCIES [J].

FIGUEROA, JE ;

DENSEN, P .

CLINICAL MICROBIOLOGY REVIEWS, 1991, 4 (03) :359-395

[4] LOW PREVALENCE OF COMPLEMENT DEFICIENCIES AMONG PATIENTS WITH MENINGOCOCCAL DISEASE IN NORWAY [J].

HOGASEN, K ;

MICHAELSEN, T ;

MELLBYE, OJ ;

BJUNE, G .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1993, 37 (04) :487-489

[5] PROPERDIN - APPROACHING 4 DECADES OF RESEARCH [J].

MAVES, KK ;

WEILER, JM .

IMMUNOLOGIC RESEARCH, 1993, 12 (03) :233-243

[6] COMPLEMENT AND IMMUNOGLOBULIN STUDIES IN 15 CASES OF CHRONIC MENINGOCOCCEMIA - PROPERDIN DEFICIENCY AND HYPOIMMUNOGLOBULINEMIA [J].

NIELSEN, HE ;

KOCH, C ;

MANSA, B ;

MAGNUSSEN, P ;

BERGMANN, OJ .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1990, 22 (01) :31-36

[7] CONGENITAL PROPERDIN DEFICIENCY AND MENINGOCOCCAL INFECTION [J].

NIELSEN, HE ;

KOCH, C .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1987, 44 (02) :134-139

[8]

PLATTSMI.TA, 1974, J IMMUNOL, V113, P348

[9] COMPLEMENT DEFICIENCY STATES AND INFECTION - EPIDEMIOLOGY, PATHOGENESIS AND CONSEQUENCES OF NEISSERIAL AND OTHER INFECTIONS IN AN IMMUNE-DEFICIENCY [J].

ROSS, SC ;

DENSEN, P .

MEDICINE, 1984, 63 (05) :243-273

[10]

SCHLESINGER M, 1990, CLIN EXP IMMUNOL, V81, P423