ANTIINFLAMMATORY ACTIVE POLYACETYLENES FROM BIDENS CAMPYLOTHECA

被引：60

作者：

REDL, K

BREU, W

DAVIS, B

BAUER, R

机构：

[1] UNIV DUSSELDORF,INST PHARMAZEUT BIOL,D-40225 DUSSELDORF,GERMANY

[2] UNIV MUNICH,INST PHARMAZEUT BIOL,D-80333 MUNICH,GERMANY

[3] PHYTOTHERAPY RES LABS,VAN NUYS,CA 91411

来源：

PLANTA MEDICA | 1994年 / 60卷 / 01期

关键词：

BIDENS CAMPYLOTHECA; COMPOSITAE; ANTIINFLAMMATORY ACTIVITY; POLYACETYLENES;

D O I：

10.1055/s-2006-959409

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E, 10E, 16-tetraene-4,6-diyne (1), heptadeca-2E,8Z, 10E, 16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new compound, safynol-2-0-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.

引用

页码：58 / 62

页数：5

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