共 21 条
[21]
Watt J.M., 1962, MED POISONOUS PLANTS, P205
ANTIINFLAMMATORY ACTIVE POLYACETYLENES FROM BIDENS CAMPYLOTHECA
被引：60
作者：
REDL, K
BREU, W
DAVIS, B
BAUER, R
机构：
[1] UNIV DUSSELDORF,INST PHARMAZEUT BIOL,D-40225 DUSSELDORF,GERMANY
[2] UNIV MUNICH,INST PHARMAZEUT BIOL,D-80333 MUNICH,GERMANY
[3] PHYTOTHERAPY RES LABS,VAN NUYS,CA 91411
关键词：
BIDENS CAMPYLOTHECA;
COMPOSITAE;
ANTIINFLAMMATORY ACTIVITY;
POLYACETYLENES;
D O I：
10.1055/s-2006-959409
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E, 10E, 16-tetraene-4,6-diyne (1), heptadeca-2E,8Z, 10E, 16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new compound, safynol-2-0-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.
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页码：58 / 62
页数：5
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