EFFECTS OF 1-ETHYNYLPYRENE AND RELATED INHIBITORS OF P450 ISOZYMES UPON BENZO[A]PYRENE METABOLISM BY LIVER-MICROSOMES

被引：26

作者：

HALL, M

PARKER, DK

GROVER, PL

LU, JYL

HOPKINS, NE

ALWORTH, WL

机构：

[1] ROYAL CANC HOSP,CHESTER BEATTY RES INST,INST CANC RES,LONDON SW3 6JB,ENGLAND

[2] TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1990年 / 76卷 / 02期

关键词：

1-Ethynylpyrene; 2-Ethynylnaphthalene; 3-Ethynylperylene; Aryl acetylenes; Benzo[a]pyrene; Benzo[a]pyrene 7,8-dihydrodiol; Microsomal metabolism; Tetrols from benzo[a]pyrene;

D O I：

10.1016/0009-2797(90)90087-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of three aryl acetylenes, 1-ethynylpyrene (EP), 2-ethynylnaphthalene (EN) and 3-ethynylperylene (EPE), upon the metabolism of benzo[a]pyrene (BaP) by microsomes isolated from rat liver were investigated. These aryl acetylenes all inhibited the total metabolism of BaP. Formation of BaP 7,8-dihydrodiol and BaP tetrol products by microsomal preparations from rats that had been pretreated with 3-methylcholanthrene (3MC) were preferentially inhibited. The effects of EP upon the metabolism of BaP 7,8-dihydrodiol by microsomes from rat liver were also studied. This aryl acetylene strongly inhibited the formation of BaP tetrols from BaP 7,8-dihydrodiol by liver microsomes both from untreated rats and from rats pretreated with 3MC, but enhanced the conversion of the BaP dihydrodiol into other metabolites. © 1990.

引用

页码：181 / 192

页数：12

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