EFFECT OF DIBUTYRYL CYCLIC AMP-TREATMENT ON PROSTAGLANDIN-F2-ALPHA-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN CULTURED RAT ASTROCYTES

被引：11

作者：

KITANAKA, J ^{[1
]}

BABA, A ^{[1
]}

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,1-6 YAMADAOKA,SUITA,OSAKA 565,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 58卷 / 02期

关键词：

D O I：

10.1254/jjp.58.189

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dibutyryl cyclic AMP (dBcAMP)-treatment of cultured rat astrocytes induced changes in astrocyte morphology followed by the potentiation of prostaglandin F2-alpha (PGF2-alpha)-stimulated phosphoinositide (PI) hydrolysis. The potentiation was observed in astrocytes of the cerebral cortex, cerebellum, and hippocampus. The dBcAMP-treatment induced agonists-specific changes in PI hydrolysis; e.g., the potentiation of norepinephrine-effect and the reduction of the carbachol-effect. Coincubations of carbachol or norepinephrine with PGF2-alpha produced additive responses.

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页码：189 / 192

页数：4

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