POLYMERIC SORBENTS FOR BILE-ACIDS .4. TREATMENT OF CHOLESTYRAMINE AS A DONNAN SYSTEM

被引：14

作者：

LEONARD, D ^{[1
]}

CLAS, SD ^{[1
]}

BROWN, GR ^{[1
]}

机构：

[1] MCGILL UNIV, DEPT CHEM, 801 SHERBROOKE ST W, MONTREAL H3A 2K6, PQ, CANADA

来源：

REACTIVE POLYMERS | 1993年 / 20卷 / 1-2期

关键词：

BILE ACIDS; SORBENTS; ION EXCHANGE; DONNAN; MICELLES; HYDROPHOBIC BINDING;

D O I：

10.1016/0923-1137(93)90073-O

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Isotherms have been determined for the in vitro sorption of cholate and glycocholate bile salt anions by cholestyramine, under various conditions of buffer and temperature. It is shown that a change in the counter-ion of the resin, from chloride to iodide, generally results in decreased sorption. Arguments based on Donnan concepts are developed to show that the binding involves ion exchange that is accompanied by the aggregation of bile salt anions within the resin phase. The derived binding constant is found to be concentration dependent, suggesting the importance of such cooperative effects.

引用

页码：131 / 140

页数：10