EFFICACY AND TOLERABILITY OF LEVODROPROPIZINE AND DROPROPIZINE IN CHILDREN WITH NONPRODUCTIVE COUGH

被引：32

作者：

BANDERALI, G

RIVA, E

FIOCCHI, A

CORDARO, CI

GIOVANNINI, M

机构：

[1] DOMPE FARMACEUT SPA,I-20122 MILAN,ITALY

[2] UNIV MILAN,SCH MED,DEPT PAEDIAT 5,MILAN,ITALY

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1995年 / 23卷 / 03期

关键词：

LEVODROPROPIZINE; DROPROPIZINE; COUGH; ANTITUSSIVES; SOMNOLENCE;

D O I：

10.1177/030006059502300304

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for efficacy. Patients randomly received either 1 mg/kg dropropizine or 2 mg/kg levodropropizine orally, three times daily for 3 days. There were statistically significant decreases in the frequency of coughing spells and nocturnal awakenings after both levodropropizine and dropropizine treatments (P < 0.001). Gastro-intestinal symptoms were mild in the two groups; somnolence was twice as frequent in the dropropizine group (10.3% vs 5.3%) and the difference is clinically relevant, though not statistically significant. Levodropropizine is as effective as an antitussive as dropropizine, but appears to carry a lower risk of daytime somnolence.

引用

页码：175 / 183

页数：9

共 21 条

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