SCH-58450, A NOVEL FARNESYL-PROTEIN TRANSFERASE INHIBITOR POSSESSING A 6A,12A-7,12-DIEPOXYBENZ[A]ANTHRACENE RING-SYSTEM

被引：13

作者：

PHIFE, DW ^{[1
]}

PATTON, RW ^{[1
]}

BERRIE, RL ^{[1
]}

YARBOROUGH, R ^{[1
]}

PUAR, MS ^{[1
]}

PATEL, M ^{[1
]}

BISHOP, WR ^{[1
]}

COVAL, SJ ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,RES INST,KENILWORTH,NJ 07033

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期

关键词：

D O I：

10.1016/0040-4039(95)01589-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

SCH 58450, a novel secondary metabolite possessing the 6a,12a:7,12-diepoxybenz[a]anthracene ring system, has been isolated from a Streptomyces sp. SCH 58450 inhibits famesyl protein transferase with an IC50 of 29 mu M and shows 25 fold selectivity for farnesyl protein transferase over geranylgexanyl protein transferase-1.

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页码：6995 / 6998

页数：4

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