PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .2. STRUCTURAL ELUCIDATION OF PEPTICINNAMIN-E

被引：68

作者：

SHIOMI, K

YANG, H

INOKOSHI, J

VANDERPYL, D

NAKAGAWA, A

TAKESHIMA, H

OMURA, S

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN

[2] TEIKYO UNIV,SCH SCI & ENGN,UTSUNOMIYA,TOCHIGI 320,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期

关键词：

D O I：

10.7164/antibiotics.46.229

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.

引用

页码：229 / 234

页数：6

共 3 条

[1] WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM STREPTOMYCES-VIOLACEUSNIGER NO-9326
HAYASHI, K
HASHIMOTO, M
SHIGEMATSU, N
NISHIKAWA, M
EZAKI, M
YAMASHITA, M
KIYOTO, S
OKUHARA, M
KOHSAKA, M
IMANAKA, H
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (07) : 1055 - 1063
[2] PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .1. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY
OMURA, S
VANDERPYL, D
INOKOSHI, J
TAKAHASHI, Y
TAKESHIMA, H
[J]. JOURNAL OF ANTIBIOTICS, 1993, 46 (02) : 222 - 228
[3] SHIGEMATSU N, UNPUB J ORG CHEM

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