PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .2. STRUCTURAL ELUCIDATION OF PEPTICINNAMIN-E

被引:68
作者
SHIOMI, K
YANG, H
INOKOSHI, J
VANDERPYL, D
NAKAGAWA, A
TAKESHIMA, H
OMURA, S
机构
[1] KITASATO INST,BIOL FUNCT RES CTR,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN
[2] TEIKYO UNIV,SCH SCI & ENGN,UTSUNOMIYA,TOCHIGI 320,JAPAN
关键词
D O I
10.7164/antibiotics.46.229
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.
引用
收藏
页码:229 / 234
页数:6
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共 3 条
  • [1] WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM STREPTOMYCES-VIOLACEUSNIGER NO-9326
    HAYASHI, K
    HASHIMOTO, M
    SHIGEMATSU, N
    NISHIKAWA, M
    EZAKI, M
    YAMASHITA, M
    KIYOTO, S
    OKUHARA, M
    KOHSAKA, M
    IMANAKA, H
    [J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (07) : 1055 - 1063
  • [2] PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .1. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY
    OMURA, S
    VANDERPYL, D
    INOKOSHI, J
    TAKAHASHI, Y
    TAKESHIMA, H
    [J]. JOURNAL OF ANTIBIOTICS, 1993, 46 (02) : 222 - 228
  • [3] SHIGEMATSU N, UNPUB J ORG CHEM