PHYSICAL-ACTIVITY EFFECTS ON BONE METABOLISM

被引:73
作者
SMITH, EL
GILLIGAN, C
机构
[1] Biogerontology Laboratory, Department of Preventive Medicine, University of Wisconsin, Madison, 53705, WI
关键词
BONE MINERAL DENSITY; EXERCISE; OSTEOPOROSIS; BONE HISTOLOGY;
D O I
10.1007/BF02555089
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The incidence of osteoporotic fractures rises exponentially with age and is increasing faster than the demographic increase in the aging population. Physical activity has great potential to reduce the risk for osteoporotic fractures. Three independent but interactive factors contribute to the risk of fractures: bone strength, the risk of falling, and the effectiveness of neuromuscular response that protects the skeleton from injury. Exercise can reduce fracture risk not only by preventing bone loss, but by decreasing the risk of falling and the force of impact by improving strength, flexibility, balance, and reaction time. Extreme inactivity causes rapid bone loss of up to 40%, while athletic activity results in bone hypertrophy of up to 40%. Exercise intervention programs have reduced bone loss or increased bone mass in both men and women of various ages and initial bone status. These benefits have been shown for arm bone mineral content, total body calcium, spine, calcium bone index, tibia, and calcaneus. In both middle-aged and elderly women, physical activity intervention reduced bone loss or increased bone mass. The mechanisms for maintenance of skeletal integrity rely on a cellular response to hormonal and mechanical load stimuli. Studies in animal models show that training affects cellular activity. In osteoporotics, cellular erosion is increased and mineral apposition rate (MAR) decreased compared with normal age-matched controls. In contrast to this, sows trained on a treadmill 20 min per day for 20 weeks had greater active periosteal surface, periosteal MAR, and osteonal MAR than untrained sows.
引用
收藏
页码:S50 / S54
页数:5
相关论文
共 42 条
[21]   PHYSICAL EXERCISE AS PROPHYLAXIS AGAINST INVOLUTIONAL VERTEBRAL BONE LOSS - A CONTROLLED TRIAL [J].
KROLNER, B ;
TOFT, B ;
NIELSEN, SP ;
TONDEVOLD, E .
CLINICAL SCIENCE, 1983, 64 (05) :541-546
[22]  
LANYON LE, 1989, TOP GERIATR REHABIL, V4, P13
[23]   EFFECT OF INTENSE PHYSICAL-ACTIVITY ON THE BONE-MINERAL CONTENT IN THE LOWER-LIMBS OF YOUNG-ADULTS [J].
MARGULIES, JY ;
SIMKIN, A ;
LEICHTER, I ;
BIVAS, A ;
STEINBERG, R ;
GILADI, M ;
STEIN, M ;
KASHTAN, H ;
MILGROM, C .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1986, 68A (07) :1090-1093
[24]  
MARTIN AD, 1991, CLIN ORTHOP RELAT R, P111
[25]  
MOROZ D, 1989, J BONE MINER RES, V4, pS233
[26]  
*NAT OST FDN, 1989, J BONE MINER RES S2, V4, P1
[27]  
NILSSON BE, 1971, CLIN ORTHOP RELAT R, P179
[28]   BONE MECHANICAL-PROPERTIES AFTER EXERCISE TRAINING IN YOUNG AND OLD RATS [J].
RAAB, DM ;
SMITH, EL ;
CRENSHAW, TD ;
THOMAS, DP .
JOURNAL OF APPLIED PHYSIOLOGY, 1990, 68 (01) :130-134
[29]   DIFFERENTIAL CHANGES IN BONE-MINERAL DENSITY OF THE APPENDICULAR AND AXIAL SKELETON WITH AGING - RELATIONSHIP TO SPINAL OSTEOPOROSIS [J].
RIGGS, BL ;
WAHNER, HW ;
DUNN, WL ;
MAZESS, RB ;
OFFORD, KP ;
MELTON, LJ .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (02) :328-335
[30]   INVOLUTIONAL OSTEOPOROSIS [J].
RIGGS, BL ;
MELTON, LJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (26) :1676-1686