SEQUENTIAL PROTEIN-KINASE REACTIONS CONTROLLING CELL-GROWTH AND DIFFERENTIATION

被引：332

作者：

JOHNSON, GL ^{[1
]}

VAILLANCOURT, RR ^{[1
]}

机构：

[1] UNIV COLORADO,SCH MED,DENVER,CO 80262

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0955-0674(94)90141-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sequential protein kinase reactions involve the phosphorylation and activation of multiple kinases in a pathway. The growth factor receptor tyrosine kinase regulation of the mitogen-activated protein kinase (MAPK) pathway was defined in 1993. The MAPK pathway involves sequential protein kinase reactions. Notable advances were made in defining tyrosine kinase receptor regulation of Ras, and these discoveries were combined with the identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP.

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页码：230 / 238

页数：9

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