3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE INHIBITORS .1. STRUCTURAL MODIFICATION OF 5-SUBSTITUTED 3,5-DIHYDROXYPENTANOIC ACIDS AND THEIR LACTONE DERIVATIVES

被引:123
作者
STOKKER, GE [1 ]
HOFFMAN, WF [1 ]
ALBERTS, AW [1 ]
CRAGOE, EJ [1 ]
DEANA, AA [1 ]
GILFILLAN, JL [1 ]
HUFF, JW [1 ]
NOVELLO, FC [1 ]
PRUGH, JD [1 ]
SMITH, RL [1 ]
WILLARD, AK [1 ]
机构
[1] MERCK SHARP & DOHME RES LABS,RAHWAY,NJ 07065
关键词
D O I
10.1021/jm00381a014
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:347 / 358
页数:12
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共 41 条
  • [1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
    ALBERTS, AW
    CHEN, J
    KURON, G
    HUNT, V
    HUFF, J
    HOFFMAN, C
    ROTHROCK, J
    LOPEZ, M
    JOSHUA, H
    HARRIS, E
    PATCHETT, A
    MONAGHAN, R
    CURRIE, S
    STAPLEY, E
    ALBERSSCHONBERG, G
    HENSENS, O
    HIRSHFIELD, J
    HOOGSTEEN, K
    LIESCH, J
    SPRINGER, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
  • [2] ALLEN CFH, 1955, ORGANIC SYNTHESES, V3
  • [3] [Anonymous], 1984, J AM MED ASS, V251, P365
  • [4] [Anonymous], 1984, J AM MED ASS, V251, P351
  • [5] IRREVERSIBLE ENZYME INHIBITORS .160. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-L-(PHENYLALKYLPHENYL)-S-TRIAZINES
    BAKER, BR
    JANSON, EE
    VERMEULEN, NM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) : 898 - +
  • [6] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM
    BROWN, AG
    SMALE, TC
    KING, TJ
    HASENKAMP, R
    THOMPSON, RH
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11): : 1165 - 1173
  • [7] BURGSTAHLER AW, 1976, SYNTHESIS-STUTTGART, P767
  • [8] ML-236A, ML-236B, AND ML-236C, NEW INHIBITORS OF CHOLESTEROGENESIS PRODUCED BY PENICILLIUM CITRINUM
    ENDO, A
    KURODA, M
    TSUJITA, Y
    [J]. JOURNAL OF ANTIBIOTICS, 1976, 29 (12) : 1346 - 1348
  • [9] FUSTER V, 1981, SCAND J HAEMATOL, V27, P1
  • [10] ATHEROSCLEROSIS AND THE BIOBEHAVIORAL SCIENCES
    HAMBURG, DA
    ELLIOTT, GR
    [J]. ARTERIOSCLEROSIS, 1982, 2 (05): : 357 - 358