TOXOPLASMOSIS ACQUIRED DURING PREGNANCY - IMPROVED SERODIAGNOSIS BASED ON AVIDITY OF IGG

被引:135
作者
LAPPALAINEN, M
KOSKELA, P
KOSKINIEMI, M
AMMALA, P
HIILESMAA, V
TERAMO, K
RAIVIO, KO
REMINGTON, JS
HEDMAN, K
机构
[1] UNIV HELSINKI,DEPT VIROL,HAARTMANNINKATU 3,SF-00290 HELSINKI 29,FINLAND
[2] UNIV HELSINKI,DEPT OBSTET & GYNECOL 1,SF-00290 HELSINKI 29,FINLAND
[3] UNIV HELSINKI,DEPT OBSTET & GYNECOL 2,SF-00290 HELSINKI 29,FINLAND
[4] UNIV HELSINKI,CHILDRENS HOSP,SF-00100 HELSINKI 10,FINLAND
[5] NATL PUBL HLTH INST,OULU,FINLAND
[6] STANFORD UNIV,MED CTR,SCH MED,STANFORD,CA 94305
[7] PALO ALTO MED RES FDN,RES INST,PALO ALTO,CA 94301
关键词
D O I
10.1093/infdis/167.3.691
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Serodiagnostic methods were evaluated in prenatal screening for primary Toxoplasma infections acquired during pregnancy in the Helsinki area. Altogether 44,181 sera were obtained consecutively during each trimester from 16,733 mothers. All IgG-containing samples were first examined by a sensitive mu-capture (IgM) ELISA, and positive results were reassessed by IgM immunoblotting and indirect IgM ELISA. An assay measuring the avidity of toxoplasma IgG was used for the first time under screening conditions. Patients suspected to have recent toxoplasmosis were reexamined by IgA ELISA and selectively by the differential agglutination assay (HS/AC test) and IgE ELISA; 16 women with diagnostic increases in IgG titer, 36 with IgM fulfilling strict specificity criteria, and 25 with IgG of low avidity were identified. The measurement of IgG avidity was a highly specific and sensitive method suitable for verification of acute primary Toxoplasma infections during pregnancy.
引用
收藏
页码:691 / 703
页数:13
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