THE IMMEDIATE VICINITY OF MOUSE METALLOTHIONEIN-I GENE CONTAINS 2 SITES CONFERRING GLUCOCORTICOID INDUCIBILITY TO THE HETEROLOGOUS PROMOTER

被引：13

作者：

PLISOV, SY ^{[1
]}

NICHIPORENKO, MG ^{[1
]}

SHKAPENKO, AL ^{[1
]}

KUMAREV, VP ^{[1
]}

BARANOVA, LV ^{[1
]}

MERKULOVA, TI ^{[1
]}

机构：

[1] GENSET,F-75001 PARIS,FRANCE

来源：

FEBS LETTERS | 1994年 / 352卷 / 03期

关键词：

METALLOTHIONEIN; GLUCOCORTICOID REGULATION; PROMOTER; REGULATORY ELEMENT;

D O I：

10.1016/0014-5793(94)00980-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucocorticoid responsive elements (GREs) located - 252 to - 209 bp upstream and + 1011 to + 1054 bp downstream of the transcription initiation site of the mouse metallotionein-I (mMT-I) gene were identified in transient transfection eperiments. However, the promoter region of the mMT-I gene (- 330 to + 70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.

引用

页码：339 / 341

页数：3

共 25 条

[1]

BEATO M, 1989, J STEROID BIOCHEM, V27, P9

[2] TISSUE SPECIFIC AND POSITION INDEPENDENT EXPRESSION OF THE COMPLETE GENE DOMAIN FOR CHICKEN LYSOZYME IN TRANSGENIC MICE [J].