QUANTITATIVE-ANALYSIS OF 8-HYDROXYGUANINE IN PERIPHERAL-BLOOD CELLS - AN APPLICATION FOR ASBESTOSIS PATIENTS

被引：19

作者：

HANAOKA, T

TSUGANE, S

YAMANO, Y

TAKAHASHI, T

KASAI, H

NATORI, Y

WATANABE, S

机构：

[1] NATL CANC CTR,DIV EPIDEMIOL,TOKYO 104,JAPAN

[2] NATL CANC CTR,DIV BIOL,TOKYO 104,JAPAN

[3] INST SCI LAB,DIV WORK ENVIRONM & OCCUPAT DIS,KANAGAWA 216,JAPAN

[4] TOKYO WOMENS MED COLL,DEPT HYGIENE & PUBL HLTH,TOKYO 160,JAPAN

[5] YOKOSUKA CHUO CLIN,KANAGAWA 213,JAPAN

来源：

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 1993年 / 65卷 / 01期

关键词：

ASBESTOSIS; BIOMARKER; ENVIRONMENTAL EPIDEMIOLOGY; 8-HYDROXY-2'-DEOXYGUANOSINE; MOLECULAR EPIDEMIOLOGY;

D O I：

10.1007/BF00381344

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The quantitative analysis of 8-hydroxy-2'-deoxyguanosine (oh8dG) in human peripheral blood cells was carried out to find integrated biomarkers for estimating cancer risk. The change of the oh8dG levels over time in two healthy volunteers was measured to evaluate a intraindividual variance and each individual value was confirmed to be almost constant when they maintained usual life style. We applied this measurement to asbestosis patients who had worked in dockyard for 19-42 years. The oh8dG were detected in all samples and ranged from 0.77 to 1.28/10(5) deoxyguanosine (dG). No significant differences was observed in mean values of oh8dG between patients (1.00+/-0.17/10(5) dG) and hospital control group without asbestos exposure (1.03+/-0.20/10(5)dG) No association was found with the status of cigarette smoking. The oh8dG level in peripheral blood cells is therefore not a sensitive biomarker for past asbestos exposure at low levels.

引用

页码：S215 / S217

页数：3

共 20 条

[11]

KASAI H, 1984, JPN J CANCER RES, V75, P841

[12]

KIYOSAWA H, 1989, MED BIOCH CHEM ASPEC, P1511

[13] MISREADING OF DNA TEMPLATES CONTAINING 8-HYDROXYDEOXYGUANOSINE AT THE MODIFIED BASE AND AT ADJACENT RESIDUES [J].