EFFECTS OF N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE AND ITS METABOLITE, N-METHYL-4-PHENYLPYRIDINIUM ION, ON DOPAMINERGIC NIGROSTRIATAL NEURONS IN THE MOUSE

被引:56
作者
PERRY, TL [1 ]
YONG, VW [1 ]
JONES, K [1 ]
WALL, RA [1 ]
CLAVIER, RM [1 ]
FOULKS, JG [1 ]
WRIGHT, JM [1 ]
机构
[1] CLARKE INST PSYCHIAT, TORONTO M5T 1R8, ONTARIO, CANADA
关键词
D O I
10.1016/0304-3940(85)90074-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:321 / 326
页数:6
相关论文
共 16 条
[1]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[2]   POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
CASTAGNOLI, N ;
CHIBA, K ;
TREVOR, AJ .
LIFE SCIENCES, 1985, 36 (03) :225-230
[3]   STUDIES ON THE MECHANISM OF ACTION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
COHEN, G ;
MYTILINEOU, C .
LIFE SCIENCES, 1985, 36 (03) :237-242
[4]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[5]   DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].
HEIKKILA, RE ;
HESS, A ;
DUVOISIN, RC .
SCIENCE, 1984, 224 (4656) :1451-1453
[6]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[7]   PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - CHARACTERIZATION AND LOCALIZATION OF RECEPTOR-BINDING SITES IN RAT AND HUMAN-BRAIN [J].
JAVITCH, JA ;
UHL, GR ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (14) :4591-4595
[8]   UPTAKE OF MPP(+) BY DOPAMINE NEURONS EXPLAINS SELECTIVITY OF PARKINSONISM-INDUCING NEUROTOXIN, MPTP [J].
JAVITCH, JA ;
SNYDER, SH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (02) :455-456
[9]   1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED PARKINSONISM IN THE COMMON MARMOSET [J].
JENNER, P ;
RUPNIAK, NMJ ;
ROSE, S ;
KELLY, E ;
KILPATRICK, G ;
LEES, A ;
MARSDEN, CD .
NEUROSCIENCE LETTERS, 1984, 50 (1-3) :85-90
[10]  
LANGSTON JW, 1984, CAN J NEUROL SCI, V11, P160