ACTIVATION OF THE SECRETORY PATHWAY LEADS TO A DECREASE IN THE INTRACELLULAR AMYLOIDOGENIC FRAGMENTS GENERATED FROM THE AMYLOID PROTEIN-PRECURSOR

被引：23

作者：

FUKUSHIMA, D

KONISHI, M

MARUYAMA, K

MIYAMOTO, T

ISHIURA, S

SUZUKI, K

机构：

[1] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN

[2] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.1804

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activation of the secretory pathway for the amyloid protein precursor (APP) by phorbol 12-myristate 13-acetate in human glioblastoma A-172 cells leads to a decrease in intracellular β-amyloidogenic fragments derived from APP. The result suggests that a metabolic switch of APP from theendosomal/lysosomal pathway to a secretion route occurs after PMA treatment. © 1993 Academic Press, Inc.

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页码：202 / 207

页数：6

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