EXPRESSION OF EPIDERMAL GROWTH-FACTOR, TRANSFORMING GROWTH FACTOR-ALPHA AND THEIR RECEPTOR IN GASTROESOPHAGEAL DISEASES

被引：34

作者：

JANKOWSKI, J

HOPWOOD, D

WORMSLEY, KG

机构：

[1] Gastrointestinal Unit, Department of Medicine, London, Lincoln’s Inn Fields

[2] Department of Pathology, University of Dundee, London, Lincoln’s Inn Fields

[3] Histopathology Unit, Imperial Cancer Research Fund, London, Lincoln’s Inn Fields

来源：

DIGESTIVE DISEASES | 1993年 / 11卷 / 01期

关键词：

BARRETTS ESOPHAGUS; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESOPHAGITIS; ESOPHAGEAL CANCER; GASTRITIS; GASTRIC CANCER; TRANSFORMING GROWTH-FACTOR-ALPHA;

D O I：

10.1159/000171396

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This article is a review of aspects of the expression of the regulatory peptides; epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and their receptor (EGF-R) in the epithelium of the human oesophagus and stomach in health and disease. It has become clear that TGF-alpha has increased expression in metaplastic, dysplastic and neoplastic tissue of the oesophagus compared with normal mucosa. The degree of abnormal expression becomes more marked as dysplasia increases. TGF-alpha expression is also increased in gastric neoplasias. EGF has a different pattern of expression, being decreased in oesophagitis and increased in gastritis. Although EGF is present in Barrett's oesophagitis, the expression of EGF does not discriminate between dysplastic and neoplastic epithelium. EGF-R is normally expressed on all gastro-intestinal epithelia, but its expression is increased in Barrett's epithelium, as well as in adenocarcinomas of the oesophagus and the stomach. The two peptides bind to their receptors on the mucosal cell membranes, and the co-expression of peptide and receptor is positively associated with varying degrees of cellular proliferation. The density of receptor expression may modulate the proliferative stimulus, leading to either mitogenic (regulated) or oncogenic (unregulated) growth.

引用

页码：1 / 11

页数：11

共 80 条

[21]

Culry A.F., Kinniburgh A.J., Krabak M.J., Huk S.-K., Wenner C.E., Induction of c-fos and c-myc proto-oncogene expression by epidermal growth factor and transforming growth factor alpha is calcium independent, J Biol Chem, 264, pp. 19700-19705, (1989)

[22]

Tsujikawa T., Bamba T., Hosoda S., The trophic effect of epidermal growth factor on morphological changes and polvamine metabolism in the small intestine of rats, Gastroenterol Jpn, 25, pp. 328-334, (1990)

[23]

Konturek S.J., Brzozowski T., Dem-Binski A., Warzeeha Z., Drozdowicz D., Garlicki J., Epidermal growth factor enhances healing of stress-induced gastric ulcerations in rats through a mechanism involving polyamines (abstract), Gastroenterology, 100, (1991)

[24]

Burgess A.W., Epidermal growth factor and transforming growth factor alpha, Br Med Bull, 45, pp. 401-424, (1990)

[25]

Carpenter G., Wahl M.I., The epidermal growth factor family, Peptide Growth Factors and Their Receptors, pp. 570-610, (1990)

[26]

Jankowski J., Tregaskis B., Coghill G., Grant A., Hopwood D., Wormsley K.G., Epidermal growth factor in esophageal diseases, Gut

[27]

Mukaida H., Yamamoto T., Hirai T., Toi M., Nakamura T., Yamashila Y., Kawano K., Niimoto M., Expression of human epidermal growth factor and its receptor in esophageal cancer, Jpn J Surg, 29, pp. 275-282, (1990)

[28]

Ishii M., Vroman B., LaRusso N.F., Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile-duct epithelial cells, Gastroenterology, 98, pp. 1284-1291, (1990)

[29]

Yoshioka K., Takemura T., Murakami K., Akano N., Matsubara K., Aya N., Maki S., Identification and localisation of epidermal growth factor and its receptor in the human glomerulus, Lab Invest, 63, pp. 189-196, (1990)

[30]

Jankowski J., Murphy S., Coghill G., Sanders S., Hopwood D., Wormsley K.G., Epidermal growth factor receptors in esophageal disease, Gut

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