A HIGH RATIO OF CHROMOGRANIN-A TO SYNAPTIN SYNAPTOPHYSIN IS A COMMON FEATURE OF BRAINS IN ALZHEIMER AND PICK DISEASE

被引：79

作者：

WEILER, R

LASSMANN, H

FISCHER, P

JELLINGER, K

WINKLER, H

机构：

[1] UNIV INNSBRUCK,DEPT PHARMACOL,PETER MAYR STR 1A,A-6020 INNSBRUCK,AUSTRIA

[2] AUSTRIAN ACAD SCI,INST BRAIN RES,A-1010 VIENNA,AUSTRIA

[3] LAINZ HOSP,LUDWIG BOLTZMANN INST CLIN NEUROBIOL,A-1090 VIENNA,AUSTRIA

[4] UNIV VIENNA,INST NEUROL,A-1010 VIENNA,AUSTRIA

来源：

FEBS LETTERS | 1990年 / 263卷 / 02期

关键词：

Alzheimer's disease; Chromogranin A; Pick's disease; Secretogranin II; Synaptin/synaptophysin;

D O I：

10.1016/0014-5793(90)81408-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromogranin A and synaptin/synaptophysin were characterized by immunological methods in human autopsy brain tissue from patients with Alzheimer's and Pick's disease. In immunoblots there was no qualitative difference between the antigens in control and diseased brain, but significant quantitative differences were found. In all Alzheimer cases there was a significantly lower level of synaptin/synaptophysin, whereas chromogranin A was higher in 4 out of 5 cases and in all cases relative to synaptin/synaptophysin. An analogous findingwas obtained for Pick's disease. Immunohistologically a consistent staining of neuritic plaques for chromogranin A, but not for secretogranin II was found in Alzheimer cases. In Pick's disease the characteristic Pick bodies showed an analogous specific immunostaining. © 1990.

引用

页码：337 / 339

页数：3

共 29 条

[11] SYNAPTIC LOSS IN ALZHEIMERS-DISEASE AND OTHER DEMENTIAS [J].