PROSPECTIVE, RANDOMIZED STUDY COMPARING AMOXICILLIN CLAVULANIC ACID AND CEFAMANDOLE FOR THE PREVENTION OF WOUND-INFECTION IN HIGH-RISK PATIENTS UNDERGOING ELECTIVE BILIARY SURGERY

被引：10

作者：

KRIGE, JEJ

ISAACS, S

STAPLETON, GN

MCNALLY, J

机构：

[1] UNIV CAPE TOWN, DEPT MED INFORMAT, CAPE TOWN 7925, SOUTH AFRICA

[2] GROOTE SCHUUR HOSP, CAPE TOWN 7925, SOUTH AFRICA

来源：

JOURNAL OF HOSPITAL INFECTION | 1992年 / 22卷

基金：

英国医学研究理事会;

关键词：

AMOXICILLIN CLAVULANIC ACID; CEFAMANDOLE; ANTIBIOTIC PROPHYLAXIS; SURGERY; BILIARY TRACT;

D O I：

10.1016/S0195-6701(05)80005-2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The efficacy of amoxycillin-clavulanic acid for prevention ofpostoperative wound infection was compared with that of cefamandole in 150 patients at risk for infected bile while undergoing elective biliary surgery in a prospective, randomized study. The two groups were comparable for age, sex, risk factors, operative procedures and positive bile cultures. Similar numbers of patients had an uncomplicated postoperative course (amoxycillin-clavulanic acid 70%; cefamandole 73%). Four patients in each group developed wound infection. The incidence of postoperative pneumonia, urinary tract infection and number of days (±SD) in hospital (amoxycillin-clavulanic acid 10·1±4·7; cefamandole 9·7±5·6) were similar. The efficacy of amoxycillin-clavulanic acid and cefamandole in preventing wound sepsis in high-risk patients undergoing biliary surgery was similar. Economic considerations may favour the use of amoxycillin-clavulanic acid. © 1992 The Hospital Infection Society.

引用

页码：33 / 41

页数：9

共 28 条

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