SYNTHESIS OF DIBENZO[A,G]QUINOLIZINES - A NEW ENTRY TO PROTOBERBERINES

被引：18

作者：

REIMANN, E

BENEND, H

机构：

来源：

MONATSHEFTE FUR CHEMIE | 1992年 / 123卷 / 10期

关键词：

REISSERT COMPOUNDS; INTRAMOLECULAR CYCLIZATION; DIBENZO[A; G]-8-QUINOLIZINONES; DEOXYGENATED CORALYNES; 8-METHYLTETRAHYDRO-PROTOBERBERINES;

D O I：

10.1007/BF00811549

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel synthesis to prepare dibenzo-8-quinolizinones 8 is reported using the intramolecular cyclisation of the benzylated Reissert compounds 6 for the key step. Methylation of 8 by methyllithium gives partial deoxygenated coralynes 10 which in turn can be reduced by NaBH4 yielding the 8-methyltetrahydro-protoberberines 11. The structures are assigned by NMR-spectroscopy.

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页码：939 / 948

页数：10

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