EVALUATION OF CENTRAL ADRENERGIC-RECEPTOR SIGNAL TRANSMISSIONS AFTER AN ANTIDEPRESSANT ADMINISTRATION TO THE RAT

被引：8

作者：

SAPENA, R ^{[1
]}

MORIN, D ^{[1
]}

ZINI, R ^{[1
]}

TILLEMENT, JP ^{[1
]}

机构：

[1] FAC MED PARIS 12,CNRS,F-94010 CRETEIL,FRANCE

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 06期

关键词：

D O I：

10.1016/0006-2952(92)90369-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of several antidepressants, amitrityline, citalopram, desipramine, fluoxetine, maprotiline, mianserin, nialamide, nomifensine, tranylcypromine and viloxazine, on the accumulation of cyclic AMP and inositol monophosphates were studied in rat cerebral cortical slices. The two enzymatic systems were stimulated either by adrenergic agonists or by forskolin. Cyclic AMP and inositol monophosphates (IPs) formed were determined by a double label method. In vitro all drugs, except inhibitors of monoamine oxidase, nialamide and tranylcypromine, inhibited alpha1-agonist-mediated production but did not modify the cyclic AMP accumulation. Otherwise, chronic desipramine but not citalopram administration decreased the accumulation of cyclic AMP (-39%) elicited by beta-adrenoceptor agonists; no change was observed in inositol phosphate metabolism after administration of these two drugs. These data support previous investigations showing a decrease in cyclic AMP production after chronic treatment with norepinephrine uptake blockers but do not confirm the hypothesis of a modification of alpha1-adrenoceptor-stimulated inositol phosphate metabolism.

引用

页码：1067 / 1072

页数：6

共 39 条

[31] DESMETHYLIMIPRAMINE-INDUCED DECREASE IN BETA-ADRENERGIC-RECEPTOR BINDING IN RAT CEREBRAL-CORTEX [J].