POSITRON EMISSION TOMOGRAPHY WITH F-18 DOPA - INTERPRETATION AND BIOLOGICAL CORRELATES IN NONHUMAN-PRIMATES

被引：13

作者：

DOUDET, DJ ^{[1
]}

AIGNER, TG ^{[1
]}

MCLELLAN, CA ^{[1
]}

COHEN, RM ^{[1
]}

机构：

[1] NIMH,NEUROPSYCHOL LAB,BETHESDA,MD 20892

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1992年 / 45卷 / 03期

关键词：

PARKINSONISM; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP); DOPAMINE; RHESUS MONKEY; UPTAKE RATE CONSTANT; AGING;

D O I：

10.1016/0925-4927(92)90023-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Positron emission tomography (PET) was carried out, with F-18-DOPA as a ligand, in normal control monkeys and ''parkinsonian'' monkeys who had been treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The following approaches were used in data analysis: ratio of F-18 accumulation in specific to nonspecific brain areas and F-18-DOPA influx constant obtained using either the actual plasma F-18-DOPA or the F-18 activity in a nonspecific brain area as the input function. The results from these analyses were compared to one another and to biological parameters relevant to dopaminergic function. The striatum/cortex ratio and the rate constant calculated from plasma F-18-DOPA appeared to be the most sensitive analytic techniques.

引用

页码：153 / 168

页数：16

共 33 条

[1] VISUAL RECOGNITION IMPAIRMENT FOLLOWS VENTROMEDIAL BUT NOT DORSOLATEAL PREFRONTAL LESIONS IN MONKEYS [J].