THE LOCAL LYMPH-NODE ASSAY - DEVELOPMENTS AND APPLICATIONS

被引：194

作者：

KIMBER, I ^{[1
]}

DEARMAN, RJ ^{[1
]}

SCHOLES, EW ^{[1
]}

BASKETTER, DA ^{[1
]}

机构：

[1] UNILEVER ENVIRONM SAFETY LAB,SHARNBROOK MK44 1LQ,BEDS,ENGLAND

来源：

TOXICOLOGY | 1994年 / 93卷 / 01期

关键词：

CONTACT SENSITIZATION; PREDICTIVE TESTING; LOCAL LYMPH NODE ASSAY;

D O I：

10.1016/0300-483X(94)90193-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The murine local lymph node assay is a predictive test method for the identification of contact allergens in which sensitizing activity is measured as a function of induced proliferative responses in lymph nodes draining the site of application. In this article the development and validation of the assay are described and comparisons with guinea pig predictive test methods discussed. In addition we examine the advantages and limitations of the method and consider new opportunities and applications of the assay in the context of the toxicological evaluation of sensitizing potential.

引用

页码：13 / 31

页数：19

共 105 条

[61] EXPERIMENTAL NICKEL SENSITIZATION IN THE GUINEA-PIG - COMPARISON OF DIFFERENT PROTOCOLS
LAMMINTAUSTA, K
KALIMO, K
JANSEN, CT
[J]. CONTACT DERMATITIS, 1985, 12 (05) : 258 - 262
[62] Studies on the sensitization of animals with simple chemical compounds
Landsteiner, K
Jacobs, J
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1935, 61 (05) : 643 - U8
[63] Landsteiner K, 1942, P SOC EXP BIOL MED, V49, P688, DOI 10.3181/00379727-49-13670
[64] IRRITANT DERMATITIS FROM TRIBUTYL TIN OXIDE AND CONTACT ALLERGY FROM CHLOROCRESOL
LEWIS, PG
EMMETT, EA
[J]. CONTACT DERMATITIS, 1987, 17 (03) : 129 - 132
[65] IDENTIFICATION OF CONTACT ALLERGENS BY ANIMAL ASSAY . GUINEA PIG MAXIMIZATION TEST
MAGNUSSON, B
KLIGMAN, AM
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1969, 52 (03) : 268 - +
[66] MAGNUSSON B, 1970, ALLERGIC CONTACT DER
[67] Maguire H C Jr, 1985, Curr Probl Dermatol, V14, P107
[68] MAGUIRE HC, 1973, J SOC COSMET CHEM, V24, P151
[69] MAGUIRE HC, 1975, ANIMAL MODELS DERMAT, P67
[70] EVALUATION OF THE SENSITIZING POTENTIAL OF 4 POLYAMINES PRESENT IN TECHNICAL TRIETHYLENETETRAMINE USING 2 ANIMAL SPECIES
MAISEY, J
PURCHASE, R
ROBBINS, MC
MILLER, K
[J]. CONTACT DERMATITIS, 1988, 18 (03) : 133 - 137

← 2 3 4 5 6 7 8 9 10 11 →