PROTEOLYSIS AT THE 2A-2B JUNCTION IN THEILERS MURINE ENCEPHALOMYELITIS VIRUS

被引：12

作者：

BATSON, S

RUNDELL, K

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,303 & CHICAGO AVE,CHICAGO,IL 60611

[2] NORTHWESTERN UNIV,SCH DENT,CHICAGO,IL 60611

[3] NORTHWESTERN UNIV,CTR CANC,CHICAGO,IL 60611

来源：

VIROLOGY | 1991年 / 181卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90914-W

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Processing at the 2A/2B junction in Theiler's murine encephalomyelitis virus (TMEV) was studied using in vitro transcription and translation. A plasmid which contained only the P2 region of TMEV was used. The protein products obtained after in vitro transcription/translation indicated that proteolysis at the 2A/2B junction occurs even if templates coding for only the 2A and 28 proteins are used. Time-course experiments indicated that 2A/2B proteolysis was cotranslational. The plasmid described will allow further definition of the sequences involved in this proteolytic event. © 1991.

引用

页码：764 / 767

页数：4

共 24 条

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