ANTITHROMBOTIC EFFECTS OF RECOMBINANT HUMAN SOLUBLE THROMBOMODULIN (RHS-TM) ON ARTERIOVENOUS SHUNT THROMBOSIS IN RATS

被引：26

作者：

AOKI, Y ^{[1
]}

TAKEI, R ^{[1
]}

MOHRI, M ^{[1
]}

GONDA, Y ^{[1
]}

GOMI, K ^{[1
]}

SUGIHARA, T ^{[1
]}

KIYOTA, T ^{[1
]}

YAMAMOTO, S ^{[1
]}

ISHIDA, T ^{[1
]}

MARUYAMA, I ^{[1
]}

机构：

[1] KAGOSHIMA UNIV,SCH MED,DEPT CLIN LAB MED,KAGOSHIMA 890,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1994年 / 47卷 / 03期

关键词：

RECOMBINANT; THROMBOMODULIN; THROMBOSIS; SHUNT; RAT; HEPARIN;

D O I：

10.1002/ajh.2830470303

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the antithrombotic effect of recombinant human soluble thrombomodulin (rhs-TM) using an arteriovenous shunt thrombosis model and its influence on hemostasis in rats. Intravenous administration of rhs-TM (0.5-4 mg/kg) significantly inhibited thrombus formation and prolonged ex vivo activated partial thromboplastin time (APTT) in a dose-dependent manner. Thrombus formation was inhibited to the same extent in animals treated with heparin (25-200 U/kg) and in those treated with rhs-TM (0.5-4 mg/kg), but heparin had a much stronger effect on prolonging APTT. In the hemorrhagic study using the rat template bleeding time method, rhs-TM exhibited the prolongation of the bleeding time only at the highest effective dose (rhs-TM; 4 mg/kg) of the thrombosis experiments. Thus, rhs-TM exhibits the inhibitory effect on thrombus formation with less APTT prolongation in comparison with heparin and without significant pertubation of hemostasis. (C) 1994 Wiley-Liss, Inc.

引用

页码：162 / 166

页数：5

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KIYOTA, T ;

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