POTENTIAL OF NATURAL PEPTIDIC COMPOUNDS AS LEADS FOR NOVEL PESTICIDES

被引：12

作者：

BLAND, JM ^{[1
]}

EDWARDS, JV ^{[1
]}

EATON, SR ^{[1
]}

LAX, AR ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,CINCINNATI,OH 45215

来源：

PESTICIDE SCIENCE | 1993年 / 39卷 / 04期

关键词：

D O I：

10.1002/ps.2780390414

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 [作物学];

摘要：

Structure-activity relationship (SAR) studies of the natural pesticidal peptide, tentoxin, are described in the context of similarity between pharmaceutical and agricultural methods of developing biologically active peptidomimetics. Essential residue substitutions that confer biological activity through predictable conformational changes in the peptide backbone and side chain functionalities are discussed. A combination of molecular modelling studies and the biological activity of natural, synthetic and photochemically transformed analogs of tentoxin is utilized to further the understanding of structural and conformational requirements for biological activity.

引用

页码：331 / 340

页数：10

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