INHIBITION OF INTRAERYTHROCYTIC DEVELOPMENT OF PLASMODIUM-FALCIPARUM BY PROTEINASE-INHIBITORS

被引：32

作者：

ROCKETT, KA

PLAYFAIR, JHL

ASHALL, F

TARGETT, GAT

ANGLIKER, H

SHAW, E

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,LONDON WC1E 7HT,ENGLAND

[2] IMPERIAL COLL SCI TECHNOL & MED,DEPT PURE & APPL BIOL,LONDON SW7 2BB,ENGLAND

[3] FRIEDRICH MIESCHER INST,CH-4002 BASEL,SWITZERLAND

来源：

FEBS LETTERS | 1990年 / 259卷 / 02期

关键词：

Antimalarial; Plasmodial inhibition; Proteinase inhibitor;

D O I：

10.1016/0014-5793(90)80022-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A group of inactivators of cysteinyl proteinases which function by covalent bond formation have been examined for their ability to inhibit thedevelopment of Plasmodium falciparum within red blood cells. The most effective of these caused inactivation of the parasite near 10-8 M concentration. The range of inhibitory action varied with peptide structure in a manner characteristic of affinity labels for proteinases suggesting that the target of inhibition was an unidentified proteinase, probably of the cysteinyl type, but different from cathepsins B and L. © 1990.

引用

页码：257 / 259

页数：3