FLOW-CYTOMETRY RESONANCE ENERGY-TRANSFER SUGGESTS AN ASSOCIATION BETWEEN LOW-AFFINITY INTERLEUKIN-2 BINDING-SITES AND HLA CLASS-I MOLECULES

被引：21

作者：

HARELBELLAN, A

KRIEF, P

RIMSKY, L

FARRAR, WL

MISHAL, Z

机构：

[1] NCI,FREDERICK CANC RES FACIL,BIOL RESPONSE MODIFIER PROGRAM,IMMUNOREGULAT LAB,FREDERICK,MD 21701

[2] HOP PAUL BROUSSE,INSERM,U268,F-94800 VILLEJUIF,FRANCE

[3] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710

[4] CNRS,CYTOMETRIE LAB,F-94800 VILLEJUIF,FRANCE

来源：

BIOCHEMICAL JOURNAL | 1990年 / 268卷 / 01期

关键词：

D O I：

10.1042/bj2680035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using flow cytometry energy transfer we have studied the sterical proximity of interleukin 2 receptors and the heavy chain of the major histocompatibility complex at the surface of normal lymphocytes. Our data suggest that class I molecules may be part of a low-affinity interleukin 2 receptor multimolecular complex, where the MHC class I heavy chain is in close proximity to the actual interleukin 2 binding site, in contrast to the light chain (β2-microglobulin).

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页码：35 / 40

页数：6

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