FLOW-CYTOMETRY RESONANCE ENERGY-TRANSFER SUGGESTS AN ASSOCIATION BETWEEN LOW-AFFINITY INTERLEUKIN-2 BINDING-SITES AND HLA CLASS-I MOLECULES

被引:21
作者
HARELBELLAN, A
KRIEF, P
RIMSKY, L
FARRAR, WL
MISHAL, Z
机构
[1] NCI,FREDERICK CANC RES FACIL,BIOL RESPONSE MODIFIER PROGRAM,IMMUNOREGULAT LAB,FREDERICK,MD 21701
[2] HOP PAUL BROUSSE,INSERM,U268,F-94800 VILLEJUIF,FRANCE
[3] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710
[4] CNRS,CYTOMETRIE LAB,F-94800 VILLEJUIF,FRANCE
关键词
D O I
10.1042/bj2680035
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using flow cytometry energy transfer we have studied the sterical proximity of interleukin 2 receptors and the heavy chain of the major histocompatibility complex at the surface of normal lymphocytes. Our data suggest that class I molecules may be part of a low-affinity interleukin 2 receptor multimolecular complex, where the MHC class I heavy chain is in close proximity to the actual interleukin 2 binding site, in contrast to the light chain (β2-microglobulin).
引用
收藏
页码:35 / 40
页数:6
相关论文
共 26 条
[11]   DETECTION OF LOW AND HIGH-AFFINITY BINDING-SITES WITH FLUORESCEINATED HUMAN RECOMBINANT INTERLEUKIN-2 [J].
HARELBELLAN, A ;
MISHAL, Z ;
WILLETTEBROWN, J ;
FARRAR, WL .
JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 119 (01) :127-133
[12]  
HARELBELLAN A, 1986, J IMMUNOL, V136, P2463
[13]   QUANTIFICATION BY FLOW CYTOFLUORIMETRY OF HLA CLASS-I MOLECULES AT THE SURFACE OF MURINE CELLS TRANSFORMED BY CLONED HLA GENES [J].
LEBOUTEILLER, PP ;
MISHAL, Z ;
LEMONNIER, FA ;
KOURILSKY, FM .
JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 61 (03) :301-315
[14]  
LIABEUF A, 1981, J IMMUNOL, V127, P1543
[15]   ANTIGEN RECOGNITION BY HUMAN LYMPHOCYTES-T IS LINKED TO SURFACE EXPRESSION OF THE T3-MOLECULAR COMPLEX [J].
REINHERZ, EL ;
MEUER, S ;
FITZGERALD, KA ;
HUSSEY, RE ;
LEVINE, H ;
SCHLOSSMAN, SF .
CELL, 1982, 30 (03) :735-743
[16]   LOW AND HIGH-AFFINITY CELLULAR RECEPTORS FOR INTERLEUKIN-2 - IMPLICATIONS FOR THE LEVEL OF TAC ANTIGEN [J].
ROBB, RJ ;
GREENE, WC ;
RUSK, CM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (04) :1126-1146
[17]   INTERLEUKIN-2 BINDING MOLECULE DISTINCT FROM THE TAC PROTEIN - ANALYSIS OF ITS ROLE IN FORMATION OF HIGH-AFFINITY RECEPTORS [J].
ROBB, RJ ;
RUSK, CM ;
YODOI, J ;
GREENE, WC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (07) :2002-2006
[18]   NOVEL INTERLEUKIN-2 RECEPTOR SUBUNIT DETECTED BY CROSS-LINKING UNDER HIGH-AFFINITY CONDITIONS [J].
SHARON, M ;
KLAUSNER, RD ;
CULLEN, BR ;
CHIZZONITE, R ;
LEONARD, WJ .
SCIENCE, 1986, 234 (4778) :859-863
[19]   THE IL-2 RECEPTOR BETA-CHAIN (P70) - ROLE IN MEDIATING SIGNALS FOR LAK, NK, AND PROLIFERATIVE ACTIVITIES [J].
SIEGEL, JP ;
SHARON, M ;
SMITH, PL ;
LEONARD, WJ .
SCIENCE, 1987, 238 (4823) :75-78
[20]   FLOW CYTOMETRIC RESONANCE ENERGY-TRANSFER MEASUREMENTS SUPPORT THE ASSOCIATION OF A 95-KDA PEPTIDE TERMED T27 WITH THE 55-KDA TAC PEPTIDE [J].
SZOLLOSI, J ;
DAMJANOVICH, S ;
GOLDMAN, CK ;
FULWYLER, MJ ;
ASZALOS, AA ;
GOLDSTEIN, G ;
RAO, P ;
TALLE, MA ;
WALDMANN, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7246-7250