EFFECTS OF ANGIOPEPTIN ON TRANSPLANT ARTERIOSCLEROSIS IN THE RAT

被引：5

作者：

AKYUREK, ML

WANDERS, A

AURIVILLIUS, M

LARSSON, E

FUNA, K

FELLSTROM, BC

机构：

[1] Department of Pathology, University Hospital, Uppsala

[2] Department of Medicine, University Hospital, Uppsala

[3] Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, S-751 24

来源：

TRANSPLANT INTERNATIONAL | 1995年 / 8卷 / 02期

关键词：

ARTERIOSCLEROSIS; ANGIOPEPTIN; RAT; AORTA TRANSPLANTATION;

D O I：

10.1007/BF00344419

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The influence of the somatostatin analogue angiopeptin on transplant arteriosclerosis was investigated using two aortic transplantation rat models. One was characterized by ischemia/reperfusion-induced changes in syngeneic transplants while immunologically induced changes dominated in the other allogeneic model. Angiopeptin, 100 mu g/kg per day, was administered continuously until the sacrifice of the rats after 8 weeks. No. additional immunosuppression was used in either model. An image analysis system was used to quantify the intimal and medial thicknesses of the grafts. In the syngeneic grafts, the intimal thickness was less than 50 % of that of control grafts (P < 0.05), but no difference was seen in the allogeneic model. The expression of selected cells, TGF-beta s, and PDGF and PDGF alpha-receptors was detected immunohistochemically and displayed a similar picture in control and angiopeptin-treated grafts in both models. We conclude that angiopeptin has no clear immunosuppressive properties but may counteract ischemia-induced transplant arteriosclerosis.

引用

页码：103 / 110

页数：8

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